Alessandra Mangia Selected Research

Ribavirin (Virazole)

1/2020	Global real-world evidence of sofosbuvir/velpatasvir as simple, effective HCV treatment: Analysis of 5552 patients from 12 cohorts.
1/2019	SVR12 Higher than 97% in GT3 Cirrhotic Patients with Evidence of Portal Hypertension Treated with SOF/VEL without Ribavirin: A Nation-Wide Cohort Study.
1/2019	SVR12 rates higher than 99% after sofosbuvir/velpatasvir combination in HCV infected patients with F0-F1 fibrosis stage: A real world experience.
1/2017	Sofosbuvir and Velpatasvir Combination Improves Patient-reported Outcomes for Patients With HCV Infection, Without or With Compensated or Decompensated Cirrhosis.
1/2017	Efficacy and safety profile of boceprevir- or telaprevir-based triple therapy or dual peginterferon alfa-2a or alfa-2b plus ribavirin therapy in chronic hepatitis C: the real-world PegBase observational study.
1/2017	Sofosbuvir and ribavirin for genotype 2 HCV infected patients with cirrhosis: A real life experience.
10/2016	Ribavirin-Free Regimen With Sofosbuvir and Velpatasvir Is Associated With High Efficacy and Improvement of Patient-Reported Outcomes in Patients With Genotypes 2 and 3 Chronic Hepatitis C: Results From Astral-2 and -3 Clinical Trials.
4/2016	Safety and efficacy of ledipasvir/sofosbuvir for the treatment of genotype 1 hepatitis C in subjects aged 65 years or older.
1/2016	The combination of daclatasvir and sofosbuvir for curing genotype 2 patients who cannot tolerate ribavirin.
12/2015	Sofosbuvir and Velpatasvir for HCV Genotype 2 and 3 Infection.

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Alessandra Mangia Research Topics

Disease

36	Infections 04/2024 - 01/2006
33	Fibrosis (Cirrhosis) 01/2024 - 03/2007
22	Chronic Hepatitis C 04/2024 - 07/2002
11	Liver Diseases (Liver Disease) 01/2023 - 05/2013
11	Hepatitis C 01/2022 - 01/2008
8	Hepatocellular Carcinoma (Hepatoma) 06/2021 - 05/2007
6	Liver Cirrhosis (Hepatic Cirrhosis) 01/2024 - 06/2009
6	Chronic Hepatitis B 01/2021 - 10/2002
5	Non-alcoholic Fatty Liver Disease 01/2024 - 01/2016
5	Hepatitis 01/2019 - 07/2002
4	COVID-19 11/2021 - 11/2020
4	Neoplasms (Cancer) 01/2015 - 08/2011
3	Fatigue 01/2017 - 05/2013
2	Nausea 01/2024 - 05/2013
2	Disease Progression 10/2022 - 06/2021
2	Fatty Liver 01/2020 - 05/2005
2	Chronic Hepatitis (Chronic Active Hepatitis) 01/2019 - 07/2002
2	Chronic Disease (Chronic Diseases) 01/2017 - 10/2016
2	Body Weight (Weight, Body) 12/2010 - 06/2005
1	Diarrhea 01/2024
1	Hepatitis D 01/2023
1	Mental Disorders (Mental Disorder) 01/2023
1	Reinfection 01/2023
1	Breakthrough Infections 01/2022
1	Alcoholic Fatty Liver 06/2021
1	Hepatitis B 01/2021
1	Chronic Kidney Failure (Chronic Renal Failure) 01/2021
1	Portal Hypertension 01/2019
1	Inflammation (Inflammations) 01/2017
1	Alcoholic Liver Diseases (Alcoholic Liver Disease) 01/2017
1	Virus Diseases (Viral Diseases) 12/2016
1	Hemorrhage 01/2016

Drug/Important Bio-Agent (IBA)

27	Ribavirin (Virazole)FDA LinkGeneric 01/2020 - 07/2002
18	SofosbuvirIBA 04/2024 - 05/2013
18	Antiviral Agents (Antivirals)IBA 01/2023 - 02/2009
14	InterferonsIBA 11/2019 - 07/2002
13	velpatasvirIBA 04/2024 - 12/2015
7	RNA (Ribonucleic Acid)IBA 01/2023 - 02/2009
7	VaccinesIBA 01/2022 - 01/2015
5	sofosbuvir drug combination ledipasvirIBA 01/2021 - 05/2014
4	telaprevirIBA 01/2017 - 06/2013
4	Proteins (Proteins, Gene)FDA Link 01/2015 - 05/2005
3	Hepatitis B e AntigensIBA 01/2023 - 01/2018
3	AntigensIBA 10/2021 - 01/2015
3	Interferon LambdaIBA 12/2020 - 08/2014
3	TabletsIBA 01/2019 - 07/2015
3	ledipasvirIBA 01/2017 - 05/2014
3	CytokinesIBA 01/2015 - 07/2010
3	NucleotidesIBA 05/2014 - 05/2013
2	Hepatitis B Surface Antigens (HBsAg)FDA Link 01/2023 - 08/2008
2	DNA (Deoxyribonucleic Acid)IBA 01/2023 - 08/2011
2	Peptides (Polypeptides)IBA 01/2022 - 01/2019
2	Biomarkers (Surrogate Marker)IBA 01/2020 - 01/2015
2	peginterferon alfa-2a (Pegasys)FDA Link 01/2017 - 05/2013
2	N- (3- amino- 1- (cyclobutylmethyl)- 2,3- dioxopropyl)- 3- (2- ((((1,1- dimethylethyl)amino)carbonyl)amino)- 3,3- dimethyl- 1- oxobutyl)- 6,6- dimethyl- 3- azabicyclo(3.1.0)hexan- 2- carboxamideIBA 01/2017 - 01/2014
2	peginterferon alfa-2b (Pegintron)FDA Link 02/2011 - 06/2005
2	Interferon-alpha (Interferon Alfa)IBA 03/2007 - 07/2002
1	Thyroid Hormone Receptors beta (TR beta)IBA 01/2024
1	resmetiromIBA 01/2024
1	Anticonvulsants (Antiepileptic Drugs)IBA 01/2023
1	AcidsIBA 01/2023
1	Triglycerides (Triacylglycerol)IBA 10/2022
1	BNT162 VaccineIBA 08/2022
1	Neutralizing AntibodiesIBA 01/2022
1	Amino Acids FDA Link 01/2022
1	sofosbuvir velpatasvir voxilaprevir drug combinationIBA 01/2022
1	Opioid Analgesics (Opioids)IBA 12/2021
1	glecaprevir and pibrentasvirIBA 01/2021
1	Membrane Proteins (Integral Membrane Proteins)IBA 01/2021
1	Hepatitis C AntibodiesIBA 11/2020
1	Protons (Proton)IBA 01/2020
1	micaIBA 01/2019
1	Tenofovir (Viread)FDA Link 01/2019
1	ProteomeIBA 01/2019
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2019
1	Interferon-gamma (Interferon, gamma)IBA 01/2019
1	Interleukin-2 (IL2)IBA 01/2019
1	vesatolimodIBA 01/2018
1	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2018
1	Protease Inhibitors (Protease Inhibitor)IBA 01/2017
1	EnzymesIBA 01/2017
1	AcyltransferasesIBA 01/2017
1	Silybin (Lagosa)IBA 04/2016
1	Genetic Markers (Genetic Marker)IBA 02/2016
1	LipidsIBA 01/2016
1	2- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA 01/2016
1	rice nuclear protein GT-2 (GT-2)IBA 01/2016
1	microsomal triglyceride transfer proteinIBA 01/2016
1	daclatasvirIBA 01/2016
1	ChemokinesIBA 01/2015
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2015

Therapy/Procedure

28	Therapeutics 01/2022 - 10/2002
6	Duration of Therapy 01/2015 - 01/2008
3	Aftercare (After-Treatment) 01/2018 - 10/2016
2	Blood Transfusion (Blood Transfusions) 08/2014 - 01/2011
1	Drug Prescriptions 01/2023
1	Liver Transplantation 06/2021
1	Withholding Treatment 01/2017
1	Opiate Substitution Treatment 12/2016
1	Contraindications 01/2016